Rank Protein Immunolabeling during Bone-Implant Interface Healing Process
The purpose of this paper was to evaluate the expression of RANK protein during bone-healing process around machined surface implants. Twenty male Wistar rats, 90 days old, after having had a 2 mm diameter and 6 mm long implant inserted in their right tibias, were evaluated at 7, 14, 21, and 42 day...
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Series: | International Journal of Dentistry |
Online Access: | http://dx.doi.org/10.1155/2010/513461 |
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doaj-8224a68c01c54e02816f69903f86b4142020-11-24T22:30:25ZengHindawi LimitedInternational Journal of Dentistry1687-87281687-87362010-01-01201010.1155/2010/513461513461Rank Protein Immunolabeling during Bone-Implant Interface Healing ProcessFrancisley Ávila Souza0Thallita Pereira Queiroz1Eloá Rodrigues Luvizuto2Renato Sussumu Nishioka3Idelmo Rangel Garcia-JR4Paulo Sérgio Perri de Carvalho5Roberta Okamoto6Department of Surgery and General Clinical, Araçatuba Dental School, Universidade Estadual Paulista, UNESP, Rua José Bonifácio 1190, Bloco 10A, Vila Mendonça, 16015-050 Araçatuba, BrazilDepartment of Surgery and General Clinical, Araçatuba Dental School, Universidade Estadual Paulista, UNESP, Rua José Bonifácio 1190, Bloco 10A, Vila Mendonça, 16015-050 Araçatuba, BrazilDepartment of Surgery and General Clinical, Araçatuba Dental School, Universidade Estadual Paulista, UNESP, Rua José Bonifácio 1190, Bloco 10A, Vila Mendonça, 16015-050 Araçatuba, BrazilDepartment of Dental Materials and Prothesis, São José dos Campos Dental School, Universidade Estadual Paulista, UNESP, BrazilDepartment of Surgery and General Clinical, Araçatuba Dental School, Universidade Estadual Paulista, UNESP, Rua José Bonifácio 1190, Bloco 10A, Vila Mendonça, 16015-050 Araçatuba, BrazilDepartment of Surgery and General Clinical, Araçatuba Dental School, Universidade Estadual Paulista, UNESP, Rua José Bonifácio 1190, Bloco 10A, Vila Mendonça, 16015-050 Araçatuba, BrazilDepartment of Surgery and General Clinical, Araçatuba Dental School, Universidade Estadual Paulista, UNESP, Rua José Bonifácio 1190, Bloco 10A, Vila Mendonça, 16015-050 Araçatuba, BrazilThe purpose of this paper was to evaluate the expression of RANK protein during bone-healing process around machined surface implants. Twenty male Wistar rats, 90 days old, after having had a 2 mm diameter and 6 mm long implant inserted in their right tibias, were evaluated at 7, 14, 21, and 42 days after healing. After obtaining the histological samples, slides were subjected to RANK immunostaining reaction. Results were quantitatively evaluated. Results. Immunolabeling analysis showed expressions of RANK in osteoclast and osteoblast lineage cells. The statistical analysis showed an increase in the expression of RANK in osteoblasts at 7 postoperative days and a gradual decrease during the chronology of the healing process demonstrated by mild cellular activity in the final stage (P<.05). Conclusion. RANK immunolabeling was observed especially in osteoclast and osteoblast cells in primary bone during the initial periods of bone-healing/implant interface.http://dx.doi.org/10.1155/2010/513461 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francisley Ávila Souza Thallita Pereira Queiroz Eloá Rodrigues Luvizuto Renato Sussumu Nishioka Idelmo Rangel Garcia-JR Paulo Sérgio Perri de Carvalho Roberta Okamoto |
spellingShingle |
Francisley Ávila Souza Thallita Pereira Queiroz Eloá Rodrigues Luvizuto Renato Sussumu Nishioka Idelmo Rangel Garcia-JR Paulo Sérgio Perri de Carvalho Roberta Okamoto Rank Protein Immunolabeling during Bone-Implant Interface Healing Process International Journal of Dentistry |
author_facet |
Francisley Ávila Souza Thallita Pereira Queiroz Eloá Rodrigues Luvizuto Renato Sussumu Nishioka Idelmo Rangel Garcia-JR Paulo Sérgio Perri de Carvalho Roberta Okamoto |
author_sort |
Francisley Ávila Souza |
title |
Rank Protein Immunolabeling during Bone-Implant Interface Healing Process |
title_short |
Rank Protein Immunolabeling during Bone-Implant Interface Healing Process |
title_full |
Rank Protein Immunolabeling during Bone-Implant Interface Healing Process |
title_fullStr |
Rank Protein Immunolabeling during Bone-Implant Interface Healing Process |
title_full_unstemmed |
Rank Protein Immunolabeling during Bone-Implant Interface Healing Process |
title_sort |
rank protein immunolabeling during bone-implant interface healing process |
publisher |
Hindawi Limited |
series |
International Journal of Dentistry |
issn |
1687-8728 1687-8736 |
publishDate |
2010-01-01 |
description |
The purpose of this paper was to evaluate the expression of RANK protein during bone-healing process around machined surface implants. Twenty male Wistar rats, 90 days old, after having had a 2 mm diameter and 6 mm long implant inserted in their right tibias, were evaluated at 7, 14, 21, and 42 days after healing. After obtaining the histological samples, slides were subjected to RANK immunostaining reaction. Results were quantitatively evaluated. Results. Immunolabeling analysis showed expressions of RANK in osteoclast and osteoblast lineage cells. The statistical analysis showed an increase in the expression of RANK in osteoblasts at 7 postoperative days and a gradual decrease during the chronology of the healing process demonstrated by mild cellular activity in the final stage (P<.05). Conclusion. RANK immunolabeling was observed especially in osteoclast and osteoblast cells in primary bone during the initial periods of bone-healing/implant interface. |
url |
http://dx.doi.org/10.1155/2010/513461 |
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