Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model

Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model

Introduction: The majority of kidneys used for transplantation are retrieved from brain-dead organ donors. In brain death, the irreversible loss of brain functions results in hemodynamic instability, hormonal changes and immunological activation. Recently, brain death has been shown to cause activat...

Full description

Bibliographic Details
Main Authors: Neeltina M. Jager, Judith E. van Zanden, Marta Subías, Henri G. D. Leuvenink, Mohamed R. Daha, Santiago Rodríguez de Córdoba, Felix Poppelaars, Marc A. Seelen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
factor B
complement
renal transplantation
brain death
donation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02528/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02528/full

Similar Items