A Novel Role for a Major Component of the Vitamin D Axis: Vitamin D Binding Protein-Derived Macrophage Activating Factor Induces Human Breast Cancer Cell Apoptosis through Stimulation of Macrophages

A Novel Role for a Major Component of the Vitamin D Axis: Vitamin D Binding Protein-Derived Macrophage Activating Factor Induces Human Breast Cancer Cell Apoptosis through Stimulation of Macrophages

The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) an...

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Bibliographic Details
Main Authors: Marco Ruggiero, Massimo Gulisano, Gabriele Morucci, Jacopo J. V. Branca, Stefano Magherini, Rodney Smith, Maria Giulia Fiore, Stefania Pacini, Lynda Thyer, Emma Ward
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Nutrients
Subjects:
vitamin D
macrophages
breast cancer
human
apoptosis
Online Access:http://www.mdpi.com/2072-6643/5/7/2577

Internet

http://www.mdpi.com/2072-6643/5/7/2577

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