Concentration-dependent mortality of chloroquine in overdose

Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment. Although generally safe they are potentially lethal in overdose. In-vitro data suggest that high concentrations and thus high doses are needed for COVID-19...

Full description

Bibliographic Details
Main Authors: James A Watson, Joel Tarning, Richard M Hoglund, Frederic J Baud, Bruno Megarbane, Jean-Luc Clemessy, Nicholas J White
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/58631