Novel lactotransferrin-derived synthetic peptides suppress cariogenic bacteria in vitro and arrest dental caries in vivo: [Novel lactotransferrin-derived anticaries peptides]

Novel lactotransferrin-derived synthetic peptides suppress cariogenic bacteria in vitro and arrest dental caries in vivo: [Novel lactotransferrin-derived anticaries peptides]

Objectives: The aim of the study was to design and synthesise novel lactotransferrin-derived antimicrobial peptides (AMPs) with enhanced antibacterial activity against cariogenic bacteria. Methods: We obtained the LF-1 (WKLLRKAWKLLRKA) and LF-2 (GKLIWKLLRKAWKLLRKA) AMPs, based on the N-terminal func...

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Bibliographic Details
Main Authors: Junyuan Luo, Zening Feng, Wentao Jiang, Xuelian Jiang, Yue Chen, Xiaohui Lv, Linglin Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Oral Microbiology
Subjects:
antimicrobial peptide
biofilm
dental caries
lactotransferrin
rat
streptococcus mutans
Online Access:http://dx.doi.org/10.1080/20002297.2021.1943999

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