Trazodone influence on rat sera beta-endorphins level

• Main Authors: Radivoj Jadrić, İrfan Zulić, Sabaheta Hasić, Emina Kiseljaković, Belma Zečević, Jovan Radovanović, Emina Ićindić-Nakaš, Mira Winterhalter-Jadrić
• Format: Article
• Language: English
• Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2004-05-01
• Series: Bosnian Journal of Basic Medical Sciences
• Subjects: β-endorphins; trazodon; rat; psychotropic drugs
• Online Access: http://www.bjbms.org/ojs/index.php/bjbms/article/view/3411

Some 25 years ago it was found that parts of CNS could produce strong analgesic response on little morphine quantities. Later studies proved the existence for dozen of morphine-like substances, called opioids, which are normally produced in the brain. The most important are endorphins, met- and leu-encephalin and dinorphin produced both in hypothalamus and pituitary gland. The aim of our study was to found whether and how strong produce of beta-endorphins is to be expected when psychotropic drugs are used. Trazodon as antidepressant was used, and RIA technique for quantification of sera beta-endorphins. The results showed significant difference in rat sera beta-endorphinsbetween certain days of drug application. These studies showed that beta-endorphins could be of great importance, used as markers for evaluation of patient treatment and eventual abuse of psychotropic drugs.