Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.

The application of RNA interference (RNAi) to mammalian cells has provided the means to perform phenotypic screens to determine the functions of genes. Although RNAi has revolutionized loss-of-function genetic experiments, it has been difficult to systematically assess the prevalence and consequence...

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Bibliographic Details
Main Authors: Ian Smith, Peyton G Greenside, Ted Natoli, David L Lahr, David Wadden, Itay Tirosh, Rajiv Narayan, David E Root, Todd R Golub, Aravind Subramanian, John G Doench
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5726721?pdf=render

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http://europepmc.org/articles/PMC5726721?pdf=render

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