Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies

Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies

Matrix metalloproteinases (MMPs) are an important family of zinc-containing enzymes with a central role in many physiological and pathological processes. Although several MMP inhibitors have been synthesized over the years, none reached the market because of off-target effects, due to the presence o...

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Bibliographic Details
Main Authors: Alessandra Ammazzalorso, Barbara De Filippis, Cristina Campestre, Antonio Laghezza, Alessandro Marrone, Rosa Amoroso, Paolo Tortorella, Mariangela Agamennone
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:International Journal of Molecular Sciences
Subjects:
MMPs
inhibitors
molecular dynamics
docking
quinoline
isoquinoline
ureas
non-zinc-binding group
Online Access:http://www.mdpi.com/1422-0067/17/10/1768

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http://www.mdpi.com/1422-0067/17/10/1768

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