Factor Xa Inhibitory Profile of Apixaban, Betrixaban, Edoxaban, and Rivaroxaban Does Not Fully Reflect Their Biologic Spectrum

The currently available oral anti-Xa agents are claimed to produce their anticoagulant and antithrombotic effects solely by the inhibition of factor Xa. This study profiled various anti-Xa drugs in routinely used laboratory assays to demonstrate that their effects are not solely related to the anti-...

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Bibliographic Details
Main Authors: Fakiha Siddiqui BDS, Debra Hoppensteadt PhD, Walter Jeske PhD, Omer Iqbal MD, Alfonso Tafur MD, Jawed Fareed PhD
Format: Article
Language:English
Published: SAGE Publishing 2019-05-01
Series:Clinical and Applied Thrombosis/Hemostasis
Online Access:https://doi.org/10.1177/1076029619847524