A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies

A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies

We assessed the sustained delivery effect of poly (lactic-co-glycolic) acid (PLGA)/vitamin E (VitE) microspheres (MSs) loaded with glial cell-derived neurotrophic factor (GDNF) alone (GDNF-MSs) or combined with brain-derived neurotrophic factor (BDNF; GDNF/BDNF-MSs) on migration of the human adult r...

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Bibliographic Details
Main Authors: Alicia Arranz-Romera, Maria Hernandez, Patricia Checa-Casalengua, Alfredo Garcia-Layana, Irene T. Molina-Martinez, Sergio Recalde, Michael J. Young, Budd A. Tucker, Rocío Herrero-Vanrell, Patricia Fernandez-Robredo, Irene Bravo-Osuna
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceuticals
Subjects:
retinal diseases
GDNF
BDNF
RPE migration
co-delivery
PLGA microspheres
Online Access:https://www.mdpi.com/1424-8247/14/1/50

Internet

https://www.mdpi.com/1424-8247/14/1/50

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