Intranasal immunization with O-2′-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles loaded with Newcastle disease virus DNA vaccine enhances mucosal immune response in chickens

Intranasal immunization with O-2′-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles loaded with Newcastle disease virus DNA vaccine enhances mucosal immune response in chickens

Abstract Background There has been a great interest in developing strategies for enhancing antigen delivery to the mucosal immune system as well as identifying mucosal active immunostimulating agents. To elevate the potential of O-2ʹ-Hydroxypropyl trimethyl ammonium chloride chitosan (O-2ʹ-HACC) as...

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Bibliographic Details
Main Authors: Kai Zhao, Beini Sun, Ci Shi, Yanwei Sun, Zheng Jin, Gaowei Hu
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Nanobiotechnology
Subjects:
Newcastle disease virus
DNA vaccine
O-2ʹ-Hydroxypropyl trimethyl ammonium chloride chitosan microparticles
Intranasal delivery
Mucosal immunity
Online Access:https://doi.org/10.1186/s12951-021-00983-5

Internet

https://doi.org/10.1186/s12951-021-00983-5

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