Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

Poly(ADP-ribose) polymerase 7 (PARP-7) has emerged as a critically important member of a large enzyme family that catalyzes ADP-ribosylation in mammalian cells. PARP-7 is a critical regulator of the innate immune response. What remains unclear is the mechanism by which PARP-7 regulates this process,...

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Bibliographic Details
Main Authors: Kelsie M Rodriguez, Sara C Buch-Larsen, Ilsa T Kirby, Ivan Rodriguez Siordia, David Hutin, Marit Rasmussen, Denis M Grant, Larry L David, Jason Matthews, Michael L Nielsen, Michael S Cohen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
ADP-ribosylation
PARPs
click chemistry
chemical genetics
proteomics
proximity labeling
Online Access:https://elifesciences.org/articles/60480

Internet

https://elifesciences.org/articles/60480

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