Variability in Tidal Volume Affects Lung and Cardiovascular Function Differentially in a Rat Model of Experimental Emphysema

Variability in Tidal Volume Affects Lung and Cardiovascular Function Differentially in a Rat Model of Experimental Emphysema

In experimental elastase-induced emphysema, mechanical ventilation with variable tidal volumes (VT) set to 30% coefficient of variation (CV) may result in more homogenous ventilation distribution, but might also impair right heart function. We hypothesized that a different CV setting could improve b...

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Bibliographic Details
Main Authors: Caio G. R. S. Wierzchon, Gisele Padilha, Nazareth N. Rocha, Robert Huhle, Mariana S. Coelho, Cintia L. Santos, Raquel S. Santos, Cynthia S. Samary, Fernanda R. G. Silvino, Paolo Pelosi, Marcelo Gama de Abreu, Patricia R. M. Rocco, Pedro L. Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Physiology
Subjects:
variable ventilation
respiratory system elastance
cardiorespiratory function
lung morphometry
inflammation
surfactant protein-D
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01071/full

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http://journal.frontiersin.org/article/10.3389/fphys.2017.01071/full

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