Pharmacological doses of daily ascorbate protect tumours from radiation damage after a single dose of radiation in an intracranial mouse glioma model

Pharmacological doses of daily ascorbate protect tumours from radiation damage after a single dose of radiation in an intracranial mouse glioma model

Pharmacological ascorbate is currently used as an anti-cancer treatment, potentially in combination with radiation therapy, by integrative medicine practitioners. In the acidic, metal-rich tumour environment, ascorbate acts as a pro-oxidant, with a mode of action similar to that of ionising radiatio...

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Bibliographic Details
Main Authors: Carole eGrasso, Marie-Sophie eFabre, Sarah V Collis, M Leticia Castro, Cameron S Field, Nanette eSchleich, Melanie J McConnell, Patries M Herst
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Oncology
Subjects:
Radiation
radioprotection
Pharmacological ascorbate
intracranial mouse glioma model
GL261
radiosensitisation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00356/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00356/full

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