Two Be or Not Two Be: The Nuclear Autoantigen La/SS-B Is able to form Dimers and Oligomers in a Redox Dependent Manner

Two Be or Not Two Be: The Nuclear Autoantigen La/SS-B Is able to form Dimers and Oligomers in a Redox Dependent Manner

According to the literature, the autoantigen La is involved in Cap-independent translation. It was proposed that one prerequisite for this function is the formation of a protein dimer. However, structural analyses argue against La protein dimers. Noteworthy to mention, these structural analyses were...

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Bibliographic Details
Main Authors: Nicole Berndt, Claudia C. Bippes, Irene Michalk, Dominik Bachmann, Jennifer Bachmann, Edinson Puentes-Cala, Tabea Bartsch, Liliana R. Loureiro, Alexandra Kegler, Ralf Bergmann, Joanne K. Gross, Tim Gross, Biji T. Kurien, R. Hal Scofield, A. Darise Farris, Judith A. James, Marc Schmitz, Karim Fahmy, Anja Feldmann, Claudia Arndt, Michael P. Bachmann
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
anti-La/SS-B antibodies
autoimmunity
La/SS-B autoantigen
systemic lupus erythematosus
primary Sjögren’s syndrome
Online Access:https://www.mdpi.com/1422-0067/22/7/3377

Internet

https://www.mdpi.com/1422-0067/22/7/3377

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