New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus <i>Penicillium</i> sp.

New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus <i>Penicillium</i> sp.

Three new andrastin-type meroterpenoids penimeroterpenoids A–C (<b>1</b>–<b>3</b>) together with two known analogs (<b>4</b> and <b>5</b>) were isolated from the cultures of the marine-derived <i>Penicillium</i> species (sp.). The structure...

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Main Authors: Jinwei Ren, Ruiyun Huo, Gaoran Liu, Ling Liu
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Marine Drugs
Subjects:
marine-derived fungus
secondary metabolites
meroterpenoids
absolute configurations
cytotoxicity
Online Access:https://www.mdpi.com/1660-3397/19/4/189
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spelling doaj-84cb555ef070497ea896a6acf18267742021-03-28T00:01:18ZengMDPI AGMarine Drugs1660-33972021-03-011918918910.3390/md19040189New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus <i>Penicillium</i> sp.Jinwei Ren0Ruiyun Huo1Gaoran Liu2Ling Liu3State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaThree new andrastin-type meroterpenoids penimeroterpenoids A–C (<b>1</b>–<b>3</b>) together with two known analogs (<b>4</b> and <b>5</b>) were isolated from the cultures of the marine-derived <i>Penicillium</i> species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of <b>1</b>–<b>3</b> were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound <b>1</b> showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines.https://www.mdpi.com/1660-3397/19/4/189marine-derived fungussecondary metabolitesmeroterpenoidsabsolute configurationscytotoxicity
collection DOAJ
language English
format Article
sources DOAJ
author Jinwei Ren
Ruiyun Huo
Gaoran Liu
Ling Liu
spellingShingle Jinwei Ren
Ruiyun Huo
Gaoran Liu
Ling Liu
New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus <i>Penicillium</i> sp.
Marine Drugs
marine-derived fungus
secondary metabolites
meroterpenoids
absolute configurations
cytotoxicity
author_facet Jinwei Ren
Ruiyun Huo
Gaoran Liu
Ling Liu
author_sort Jinwei Ren
title New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus <i>Penicillium</i> sp.
title_short New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus <i>Penicillium</i> sp.
title_full New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus <i>Penicillium</i> sp.
title_fullStr New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus <i>Penicillium</i> sp.
title_full_unstemmed New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus <i>Penicillium</i> sp.
title_sort new andrastin-type meroterpenoids from the marine-derived fungus <i>penicillium</i> sp.
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2021-03-01
description Three new andrastin-type meroterpenoids penimeroterpenoids A–C (<b>1</b>–<b>3</b>) together with two known analogs (<b>4</b> and <b>5</b>) were isolated from the cultures of the marine-derived <i>Penicillium</i> species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of <b>1</b>–<b>3</b> were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound <b>1</b> showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines.
topic marine-derived fungus
secondary metabolites
meroterpenoids
absolute configurations
cytotoxicity
url https://www.mdpi.com/1660-3397/19/4/189
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AT gaoranliu newandrastintypemeroterpenoidsfromthemarinederivedfungusipenicilliumisp
AT lingliu newandrastintypemeroterpenoidsfromthemarinederivedfungusipenicilliumisp
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