The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil
We investigated the impact of multidrug therapy (MDT) on the epidemiological pattern of leprosy in Juiz de Fora, Brazil, from 1978 to 1995. Evaluation of 1,283 medical charts was performed according to the treatment regimen used in two different periods. Following the introduction of MDT in 1987, pr...
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Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
2000-01-01
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doaj-84d06532d820449e826dde81c6a83f412020-11-25T01:57:07ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-44642000-01-01162343350The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, BrazilSoares Luzivander S.Moreira Rodrigo de O.Vilela Vanessa V.Alves Márcio J. M.Pimentel Ana Flávia M.Ferreira Ana PaulaTeixeira Henrique C.We investigated the impact of multidrug therapy (MDT) on the epidemiological pattern of leprosy in Juiz de Fora, Brazil, from 1978 to 1995. Evaluation of 1,283 medical charts was performed according to the treatment regimen used in two different periods. Following the introduction of MDT in 1987, prevalence of leprosy decreased from 22 patients/10,000 inhabitants to 5.2 patients/10,000 inhabitants in 1995. Incidence rate of leprosy was lower in period II (1987-1995) than in period I (1978-1986). Decreasing prevalence and incidence appear to be related to drug efficacy rather than decreased case identification, since both self-referred and professionally referred treatment increased markedly from period I to period II. For both periods, multibacillary leprosy was the most frequent clinical form of the disease (±68%), and the main infection risk factor identified was household contact. Leprosy is predominantly manifested in adults, but an increase in the number of very old and very young patients was observed in period II. The MDT program has been effective both in combating leprosy and in promoting awareness of the disease.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X2000000200005LeprosyCombination Drug TherapyPrevalenceEpidemiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soares Luzivander S. Moreira Rodrigo de O. Vilela Vanessa V. Alves Márcio J. M. Pimentel Ana Flávia M. Ferreira Ana Paula Teixeira Henrique C. |
spellingShingle |
Soares Luzivander S. Moreira Rodrigo de O. Vilela Vanessa V. Alves Márcio J. M. Pimentel Ana Flávia M. Ferreira Ana Paula Teixeira Henrique C. The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil Cadernos de Saúde Pública Leprosy Combination Drug Therapy Prevalence Epidemiology |
author_facet |
Soares Luzivander S. Moreira Rodrigo de O. Vilela Vanessa V. Alves Márcio J. M. Pimentel Ana Flávia M. Ferreira Ana Paula Teixeira Henrique C. |
author_sort |
Soares Luzivander S. |
title |
The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil |
title_short |
The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil |
title_full |
The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil |
title_fullStr |
The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil |
title_full_unstemmed |
The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil |
title_sort |
impact of multidrug therapy on the epidemiological pattern of leprosy in juiz de fora, brazil |
publisher |
Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
series |
Cadernos de Saúde Pública |
issn |
0102-311X 1678-4464 |
publishDate |
2000-01-01 |
description |
We investigated the impact of multidrug therapy (MDT) on the epidemiological pattern of leprosy in Juiz de Fora, Brazil, from 1978 to 1995. Evaluation of 1,283 medical charts was performed according to the treatment regimen used in two different periods. Following the introduction of MDT in 1987, prevalence of leprosy decreased from 22 patients/10,000 inhabitants to 5.2 patients/10,000 inhabitants in 1995. Incidence rate of leprosy was lower in period II (1987-1995) than in period I (1978-1986). Decreasing prevalence and incidence appear to be related to drug efficacy rather than decreased case identification, since both self-referred and professionally referred treatment increased markedly from period I to period II. For both periods, multibacillary leprosy was the most frequent clinical form of the disease (±68%), and the main infection risk factor identified was household contact. Leprosy is predominantly manifested in adults, but an increase in the number of very old and very young patients was observed in period II. The MDT program has been effective both in combating leprosy and in promoting awareness of the disease. |
topic |
Leprosy Combination Drug Therapy Prevalence Epidemiology |
url |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X2000000200005 |
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