MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, pr...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-01-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/60191 |