Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic Glycolysis
Lung adenocarcinoma (LUAD) accounts for ~30% of all lung cancers and is one of the causes of cancer-related death worldwide. As the role of monoamine oxidase A (MAOA) in LUAD remains unclear, in this study, we examine how MAOA affects LUAD cell proliferation. Analyses of both public data and our dat...
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Frontiers Media S.A.
2021-03-01
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doaj-8593b1e6530a4d0c8922908ba2a9c7dc2021-03-08T05:50:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.645821645821Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic GlycolysisYumin Huang0Yumin Huang1Wei Zhao2Xiaoping Ouyang3Feng Wu4Yujian Tao5Minhua Shi6Department of Respiratory Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou, ChinaSchool of Laboratory Medicine/Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-Origin Food, Chengdu Medical College, Chengdu, ChinaDepartment of Respiratory Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou, ChinaDepartment of Respiratory Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou, ChinaDepartment of Respiratory Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou, ChinaDepartment of Respiratory Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaLung adenocarcinoma (LUAD) accounts for ~30% of all lung cancers and is one of the causes of cancer-related death worldwide. As the role of monoamine oxidase A (MAOA) in LUAD remains unclear, in this study, we examine how MAOA affects LUAD cell proliferation. Analyses of both public data and our data reveal that the expression of MAOA is downregulated in LUAD compared with non-tumor tissue. In addition, the expression of MAOA in tumors correlates with clinicopathologic features, and the expression of MAOA serves as an independent biomarker in LUAD. In addition, the overexpression of MAOA inhibits LUAD cell proliferation by inducing G1 arrest in vitro. Further mechanistic studies show that MAOA abrogates aerobic glycolysis in LUAD cells by decreasing hexokinase 2 (HK2). Finally, the expression of HK2 shows a negative correlation with MAOA in LUAD, and high HK2 predicts poor clinical outcome. In conclusion, our findings indicate that MAOA functions as a tumor suppressor in LUAD. Our results indicate that the MAOA/HK2 axis could be potential targets in LUAD therapy.https://www.frontiersin.org/articles/10.3389/fonc.2021.645821/fulllung adenocarcinomamonoamine oxidase Aaerobic glycolysishexokinase 2cell prolferation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yumin Huang Yumin Huang Wei Zhao Xiaoping Ouyang Feng Wu Yujian Tao Minhua Shi |
spellingShingle |
Yumin Huang Yumin Huang Wei Zhao Xiaoping Ouyang Feng Wu Yujian Tao Minhua Shi Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic Glycolysis Frontiers in Oncology lung adenocarcinoma monoamine oxidase A aerobic glycolysis hexokinase 2 cell prolferation |
author_facet |
Yumin Huang Yumin Huang Wei Zhao Xiaoping Ouyang Feng Wu Yujian Tao Minhua Shi |
author_sort |
Yumin Huang |
title |
Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic Glycolysis |
title_short |
Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic Glycolysis |
title_full |
Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic Glycolysis |
title_fullStr |
Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic Glycolysis |
title_full_unstemmed |
Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic Glycolysis |
title_sort |
monoamine oxidase a inhibits lung adenocarcinoma cell proliferation by abrogating aerobic glycolysis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-03-01 |
description |
Lung adenocarcinoma (LUAD) accounts for ~30% of all lung cancers and is one of the causes of cancer-related death worldwide. As the role of monoamine oxidase A (MAOA) in LUAD remains unclear, in this study, we examine how MAOA affects LUAD cell proliferation. Analyses of both public data and our data reveal that the expression of MAOA is downregulated in LUAD compared with non-tumor tissue. In addition, the expression of MAOA in tumors correlates with clinicopathologic features, and the expression of MAOA serves as an independent biomarker in LUAD. In addition, the overexpression of MAOA inhibits LUAD cell proliferation by inducing G1 arrest in vitro. Further mechanistic studies show that MAOA abrogates aerobic glycolysis in LUAD cells by decreasing hexokinase 2 (HK2). Finally, the expression of HK2 shows a negative correlation with MAOA in LUAD, and high HK2 predicts poor clinical outcome. In conclusion, our findings indicate that MAOA functions as a tumor suppressor in LUAD. Our results indicate that the MAOA/HK2 axis could be potential targets in LUAD therapy. |
topic |
lung adenocarcinoma monoamine oxidase A aerobic glycolysis hexokinase 2 cell prolferation |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.645821/full |
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