Reduced <i>USP22</i> Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis

Reduced <i>USP22</i> Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis

Chromosome instability (CIN) is an enabling feature of oncogenesis associated with poor patient outcomes, whose genetic determinants remain largely unknown. As mitotic chromatin compaction defects can compromise the accuracy of chromosome segregation into daughter cells and drive CIN, characterizing...

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Bibliographic Details
Main Authors: Lucile M. Jeusset, Brent J. Guppy, Zelda Lichtensztejn, Darin McDonald, Kirk J. McManus
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
chromosome instability
<i>USP22</i>
H2B ubiquitination
H2Bub1
quantitative imaging microscopy
cancer
Online Access:https://www.mdpi.com/2072-6694/13/5/1043

Internet

https://www.mdpi.com/2072-6694/13/5/1043

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