A multi-site validation in India of the line probe assay for the rapid diagnosis of multi-drug resistant tuberculosis directly from sputum specimens.

A multi-site validation in India of the line probe assay for the rapid diagnosis of multi-drug resistant tuberculosis directly from sputum specimens.

Rifampicin (R) and isoniazid (H) are key first-line anti-tuberculosis drugs. Failure to detect resistance to these two drugs early results in treatment failure and poor clinical outcomes. The study purpose was to validate the use of the GenoType MTBDRplus line probe assay (LPA) to detect resistance...

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Bibliographic Details
Main Authors: Neeraj Raizada, K S Sachdeva, D S Chauhan, Bharti Malhotra, Kishore Reddy, P V Dave, Yamuna Mundade, Pranav Patel, Ranjani Ramachandran, Ram Das, Rajesh Solanki, Douglas Fraser Wares, Suvanand Sahu, Rick O'Brien, C N Paramasivan, Puneet K Dewan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3929364?pdf=render

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http://europepmc.org/articles/PMC3929364?pdf=render

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