High-throughput miRNA and mRNA sequencing of paired colorectal normal, tumor and metastasis tissues and bioinformatic modeling of miRNA-1 therapeutic applications.

MiRNAs are discussed as diagnostic and therapeutic molecules. However, effective miRNA drug treatments with miRNAs are, so far, hampered by the complexity of the miRNA networks. To identify potential miRNA drugs in colorectal cancer, we profiled miRNA and mRNA expression in matching normal, tumor an...

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Main Authors: Christina Röhr, Martin Kerick, Axel Fischer, Alexander Kühn, Karl Kashofer, Bernd Timmermann, Andriani Daskalaki, Thomas Meinel, Dmitriy Drichel, Stefan T Börno, Anja Nowka, Sylvia Krobitsch, Alice C McHardy, Christina Kratsch, Tim Becker, Andrea Wunderlich, Christian Barmeyer, Christian Viertler, Kurt Zatloukal, Christoph Wierling, Hans Lehrach, Michal R Schweiger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3707605?pdf=render