Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss
Volumetric muscle loss leads to functional muscle impairment, and current stem cell-based treatments show limited efficacy. Here, the authors generate a stem cell scaffold, implant it in mice, and show that an exercise regimen enhances innervation and restoration of muscle function in mice.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15613 |
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doaj-866687b376184d498404013b22fd5a49 |
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doaj-866687b376184d498404013b22fd5a492021-05-11T07:37:43ZengNature Publishing GroupNature Communications2041-17232017-06-018111710.1038/ncomms15613Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle lossMarco Quarta0Melinda Cromie1Robert Chacon2Justin Blonigan3Victor Garcia4Igor Akimenko5Mark Hamer6Patrick Paine7Merel Stok8Joseph B. Shrager9Thomas A. Rando10Department of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Hematology and Department of Pediatrics, Erasmus Medical CenterDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine and VA Palo Alto Health Care SystemDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineVolumetric muscle loss leads to functional muscle impairment, and current stem cell-based treatments show limited efficacy. Here, the authors generate a stem cell scaffold, implant it in mice, and show that an exercise regimen enhances innervation and restoration of muscle function in mice.https://doi.org/10.1038/ncomms15613 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marco Quarta Melinda Cromie Robert Chacon Justin Blonigan Victor Garcia Igor Akimenko Mark Hamer Patrick Paine Merel Stok Joseph B. Shrager Thomas A. Rando |
| spellingShingle |
Marco Quarta Melinda Cromie Robert Chacon Justin Blonigan Victor Garcia Igor Akimenko Mark Hamer Patrick Paine Merel Stok Joseph B. Shrager Thomas A. Rando Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss Nature Communications |
| author_facet |
Marco Quarta Melinda Cromie Robert Chacon Justin Blonigan Victor Garcia Igor Akimenko Mark Hamer Patrick Paine Merel Stok Joseph B. Shrager Thomas A. Rando |
| author_sort |
Marco Quarta |
| title |
Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss |
| title_short |
Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss |
| title_full |
Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss |
| title_fullStr |
Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss |
| title_full_unstemmed |
Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss |
| title_sort |
bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-06-01 |
| description |
Volumetric muscle loss leads to functional muscle impairment, and current stem cell-based treatments show limited efficacy. Here, the authors generate a stem cell scaffold, implant it in mice, and show that an exercise regimen enhances innervation and restoration of muscle function in mice. |
| url |
https://doi.org/10.1038/ncomms15613 |
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1721451905876492288 |