Synthesis, Cytotoxic Activity Evaluation and Quantitative Structure‐Activity Analysis of Substituted 5,8-Dihydroxy-1,4‐Naphthoquinones and their <i>O</i>- and <i>S</i>-Glycoside Derivatives Tested Against Neuro-2a Cancer Cells

Synthesis, Cytotoxic Activity Evaluation and Quantitative Structure‐Activity Analysis of Substituted 5,8-Dihydroxy-1,4‐Naphthoquinones and their <i>O</i>- and <i>S</i>-Glycoside Derivatives Tested Against Neuro-2a Cancer Cells

Based on 6,7-substituted 2,5,8-trihydroxy-1,4-naphtoquinones (1,4-NQs) derived from sea urchins, five new acetyl-<i>O</i>-glucosides of NQs were prepared. A new method of conjugation of per-<i>O</i>-acetylated 1-mercaptosaccharides with 2-hydroxy-1,4-NQs through a methylene s...

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Bibliographic Details
Main Authors: Sergey Polonik, Galina Likhatskaya, Yuri Sabutski, Dmitry Pelageev, Vladimir Denisenko, Evgeny Pislyagin, Ekaterina Chingizova, Ekaterina Menchinskaya, Dmitry Aminin
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Marine Drugs
Subjects:
neuroblastoma Neuro-2a cells
5,8-dihydroxy-1,4-naphthoquinone
<i>O</i>-glucoside
thiomethylglycoside
cytotoxic activity
QSAR
Online Access:https://www.mdpi.com/1660-3397/18/12/602

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https://www.mdpi.com/1660-3397/18/12/602

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