Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N<sub>2</sub> in Dendritic Cells to Protect from Elevated Colitis

Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N<sub>2</sub> in Dendritic Cells to Protect from Elevated Colitis

Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Mice lacking PTPN2 in dendritic cells (DCs) develop skin and liver inflammation by the age of 22 weeks due to a generalized loss of tolerance leading to uncontrolle...

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Bibliographic Details
Main Authors: Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Anna Niechcial, Julianne B. Riggs, Marcin Wawrzyniak, Kirstin Atrott, Marnix van de Sande, Silvia Lang, Burkhard Becher, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
PTPN2
dendritic cells
inflammatory bowel disease
colitis
Online Access:https://www.mdpi.com/1422-0067/22/13/6820

Internet

https://www.mdpi.com/1422-0067/22/13/6820

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