Selective Neural Deletion of the Atg7 Gene Reduces Irradiation-Induced Cerebellar White Matter Injury in the Juvenile Mouse Brain by Ameliorating Oligodendrocyte Progenitor Cell Loss

Selective Neural Deletion of the Atg7 Gene Reduces Irradiation-Induced Cerebellar White Matter Injury in the Juvenile Mouse Brain by Ameliorating Oligodendrocyte Progenitor Cell Loss

Radiotherapy is an effective tool for treating brain tumors, but irradiation-induced toxicity to the normal brain tissue remains a major problem. Here, we investigated if selective neural autophagy related gene 7 (Atg7) deletion has a persistent effect on irradiation-induced juvenile mouse brain inj...

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Bibliographic Details
Main Authors: Yafeng Wang, Kai Zhou, Tao Li, Yiran Xu, Cuicui Xie, Yanyan Sun, Juan Rodriguez, Shan Zhang, Juan Song, Xiaoyang Wang, Klas Blomgren, Changlian Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
autophagy
cell proliferation
inflammation
microglia
oligodendrocyte progenitor cells
astrocyte
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00241/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00241/full

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