The Role of Immune Checkpoint Receptors in Regulating Immune Reactivity in Lupus

The Role of Immune Checkpoint Receptors in Regulating Immune Reactivity in Lupus

Immune checkpoint receptors with co-stimulatory and co-inhibitory signals are important modulators for the immune system. However, unrestricted co-stimulation and/or inadequate co-inhibition may cause breakdown of self-tolerance, leading to autoimmunity. Systemic lupus erythematosus (SLE) is a compl...

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Bibliographic Details
Main Authors: Kun-Lin Lu, Ming-Ying Wu, Chi-Hui Wang, Chuang-Wei Wang, Shuen-Iu Hung, Wen-Hung Chung, Chun-Bing Chen
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
autoimmunity
co-stimulatory signals
co-inhibitory signals
immune checkpoint
immune regulation
immune-related adverse events
systemic lupus erythematosus
Online Access:https://www.mdpi.com/2073-4409/8/10/1213

Internet

https://www.mdpi.com/2073-4409/8/10/1213

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