Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection

Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection

. TGFβ is critical for limiting autoreactive responses of peripheral T cells. Here, the authors show that TGFβ signaling in thymocytes mediates elimination of self-reactive T cells and promotes the expression of self-antigens by medullary thymic epithelial cells.

Bibliographic Details
Main Authors: Mark J. McCarron, Magali Irla, Arnauld Sergé, Saidi M’Homa Soudja, Julien C. Marie
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13456-z
Description
Summary:. TGFβ is critical for limiting autoreactive responses of peripheral T cells. Here, the authors show that TGFβ signaling in thymocytes mediates elimination of self-reactive T cells and promotes the expression of self-antigens by medullary thymic epithelial cells.
ISSN:2041-1723

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