Comparison common equations for LDL-C calculation with direct assay and developing a novel formula in Iranian children and adolescents: the CASPIAN V study
Abstract Background Hypercholesterolemia is a common dyslipidemia that leads to atherosclerosis. It is proved that early stages of atherosclerosis begins in early stages of life. In several studies, widespread prevalence of dyslipidemia in children is reported. So, assessment of lipid profile in chi...
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doaj-87c174f291d041cea12f0129dcce8b6b2020-11-25T03:41:43ZengBMCLipids in Health and Disease1476-511X2020-06-011911810.1186/s12944-020-01306-7Comparison common equations for LDL-C calculation with direct assay and developing a novel formula in Iranian children and adolescents: the CASPIAN V studyFatemeh Molavi0Nazli Namazi1Mojgan Asadi2Mahnaz Sanjari3Mohammad Esmaeil Motlagh4Gita Shafiee5Mostafa Qorbani6Ramin Heshmat7Roya Kelishadi8Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesDepartment of Pediatrics, Ahvaz Jundishapur University of Medical SciencesChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-communicable Diseases Research Center, Alborz University of Medical SciencesChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesChild Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical SciencesAbstract Background Hypercholesterolemia is a common dyslipidemia that leads to atherosclerosis. It is proved that early stages of atherosclerosis begins in early stages of life. In several studies, widespread prevalence of dyslipidemia in children is reported. So, assessment of lipid profile in children and adolescence is necessary for early diagnosis of dyslipidemia. Laboratory methods for measuring LDL are not available and economical. So, in some laboratories Friedwald method is used to determine LDL level. But, the preciseness of this method is not acceptable. Further, the preciseness of this method was not assayed in children and adolescence. So, it seems that assaying the preciseness of different methods is necessary. Methods The methodology of this work is on the basis of findings of the Caspian V study. This study was conducted in 30 provinces of Iran during 2015. The population of this work was rural and urban students aged 7–18 years old. The level of total cholesterol (TC), HDL, LDL, and TG were measured using laboratory methods. The average and variances values were determined for each group of data using SPSS. Further, LDL values were calculated with a new formula introduced in this work. A comparison was made between the new formula and the other methods. Results In the present study, we found that compare to four common formulas, Friedwald was the best equation to estimate LDL-C concentrations in Iranian children and adolescents and the new formula was the next accurate equation. The strongest correlation between Friedwald and the new equation was found for those with 15–18 years old. Conclusion Considering the cut-off points of TG (100 mg/dL), we observed the strongest correlation between Friedwald equation and direct assay and the weakest one was for Ahmadi formula in subjects with either greater or lower TG concentrations. Furthermore, we found that Anandraja equation had the most sensitivity (89.5%), while the most specificity was dedicated to the new formula (98.9%).http://link.springer.com/article/10.1186/s12944-020-01306-7LDL levelTriglycerideChildren and adolescent |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fatemeh Molavi Nazli Namazi Mojgan Asadi Mahnaz Sanjari Mohammad Esmaeil Motlagh Gita Shafiee Mostafa Qorbani Ramin Heshmat Roya Kelishadi |
spellingShingle |
Fatemeh Molavi Nazli Namazi Mojgan Asadi Mahnaz Sanjari Mohammad Esmaeil Motlagh Gita Shafiee Mostafa Qorbani Ramin Heshmat Roya Kelishadi Comparison common equations for LDL-C calculation with direct assay and developing a novel formula in Iranian children and adolescents: the CASPIAN V study Lipids in Health and Disease LDL level Triglyceride Children and adolescent |
author_facet |
Fatemeh Molavi Nazli Namazi Mojgan Asadi Mahnaz Sanjari Mohammad Esmaeil Motlagh Gita Shafiee Mostafa Qorbani Ramin Heshmat Roya Kelishadi |
author_sort |
Fatemeh Molavi |
title |
Comparison common equations for LDL-C calculation with direct assay and developing a novel formula in Iranian children and adolescents: the CASPIAN V study |
title_short |
Comparison common equations for LDL-C calculation with direct assay and developing a novel formula in Iranian children and adolescents: the CASPIAN V study |
title_full |
Comparison common equations for LDL-C calculation with direct assay and developing a novel formula in Iranian children and adolescents: the CASPIAN V study |
title_fullStr |
Comparison common equations for LDL-C calculation with direct assay and developing a novel formula in Iranian children and adolescents: the CASPIAN V study |
title_full_unstemmed |
Comparison common equations for LDL-C calculation with direct assay and developing a novel formula in Iranian children and adolescents: the CASPIAN V study |
title_sort |
comparison common equations for ldl-c calculation with direct assay and developing a novel formula in iranian children and adolescents: the caspian v study |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2020-06-01 |
description |
Abstract Background Hypercholesterolemia is a common dyslipidemia that leads to atherosclerosis. It is proved that early stages of atherosclerosis begins in early stages of life. In several studies, widespread prevalence of dyslipidemia in children is reported. So, assessment of lipid profile in children and adolescence is necessary for early diagnosis of dyslipidemia. Laboratory methods for measuring LDL are not available and economical. So, in some laboratories Friedwald method is used to determine LDL level. But, the preciseness of this method is not acceptable. Further, the preciseness of this method was not assayed in children and adolescence. So, it seems that assaying the preciseness of different methods is necessary. Methods The methodology of this work is on the basis of findings of the Caspian V study. This study was conducted in 30 provinces of Iran during 2015. The population of this work was rural and urban students aged 7–18 years old. The level of total cholesterol (TC), HDL, LDL, and TG were measured using laboratory methods. The average and variances values were determined for each group of data using SPSS. Further, LDL values were calculated with a new formula introduced in this work. A comparison was made between the new formula and the other methods. Results In the present study, we found that compare to four common formulas, Friedwald was the best equation to estimate LDL-C concentrations in Iranian children and adolescents and the new formula was the next accurate equation. The strongest correlation between Friedwald and the new equation was found for those with 15–18 years old. Conclusion Considering the cut-off points of TG (100 mg/dL), we observed the strongest correlation between Friedwald equation and direct assay and the weakest one was for Ahmadi formula in subjects with either greater or lower TG concentrations. Furthermore, we found that Anandraja equation had the most sensitivity (89.5%), while the most specificity was dedicated to the new formula (98.9%). |
topic |
LDL level Triglyceride Children and adolescent |
url |
http://link.springer.com/article/10.1186/s12944-020-01306-7 |
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