Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future

• Main Authors: Arezoo Asadi, Milad Abdi, Ebrahim Kouhsari, Pegah Panahi, Mohammad Sholeh, Nourkhoda Sadeghifard, Taghi Amiriani, Alireza Ahmadi, Abbas Maleki, Mehrdad Gholami
• Format: Article
• Language: English
• Published: Elsevier 2020-09-01
• Series: Journal of Global Antimicrobial Resistance
• Subjects: Minocycline resistance; Minocycline antibacterial activity; Mechanisms of minocycline resistance; Minocycline clinical effectiveness
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213716520300230

Objectives: The increasing crisis regarding multidrug-resistant (MDR) and extensively drug-resistant microorganisms leads to appealing therapeutic options. Methods: During the last 30 years, minocycline, a wide-spectrum antimicrobial agent, has been effective against MDR Gram-positive and Gram-negative bacterial infections. As with other tetracyclines, the mechanism of action of minocycline involves attaching to the bacterial 30S ribosomal subunit and preventing protein synthesis. Results: This antimicrobial agent has been approved for the treatment of acne vulgaris, some sexually transmitted diseases and rheumatoid arthritis. Although many reports have been published, there remains limited information regarding the prevalence, mechanism of resistance and clinical effectiveness of minocycline. Conclusion: Thus, we summarize here the currently available data concerning pharmacokinetics and pharmacodynamics, mechanism of action and resistance, antibacterial activity and clinical effectiveness of minocycline.