B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes

B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes

B cells have been strongly implicated in the development of human type 1 diabetes and are required for disease in the NOD mouse model. These functions are dependent on B cell antigen receptor (BCR) specificity and expression of MHC, implicating linked autoantigen recognition and presentation to effe...

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Bibliographic Details
Main Authors: Thomas A. Packard, Mia J. Smith, Francis J. Conrad, Sara A. Johnson, Andrew Getahun, Robin S. Lindsay, Rochelle M. Hinman, Rachel S. Friedman, James W. Thomas, John C. Cambier
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Journal of Clinical Medicine
Subjects:
BCR
B cell antigen receptor
insulin
type 1 diabetes (T1D)
non-obese diabetic mouse (NOD)
Online Access:http://www.mdpi.com/2077-0383/5/11/98

Internet

http://www.mdpi.com/2077-0383/5/11/98

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