Exercise and obesity-induced insulin resistance in skeletal muscle
The skeletal muscle in our body is a major site for bioenergetics and metabolism during exercise. Carbohydrates and fats are the primary nutrients that provide the necessary energy required to maintain cellular activities during exercise. The metabolic responses to exercise in glucose and lipid regu...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2013-12-01
|
Series: | Integrative Medicine Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221342201300070X |
id |
doaj-88018fd4d31741978da0b590c25a3b66 |
---|---|
record_format |
Article |
spelling |
doaj-88018fd4d31741978da0b590c25a3b662020-11-24T22:55:57ZengElsevierIntegrative Medicine Research2213-42202013-12-012413113810.1016/j.imr.2013.09.004Exercise and obesity-induced insulin resistance in skeletal muscleHyo-Bum KwakThe skeletal muscle in our body is a major site for bioenergetics and metabolism during exercise. Carbohydrates and fats are the primary nutrients that provide the necessary energy required to maintain cellular activities during exercise. The metabolic responses to exercise in glucose and lipid regulation depend on the intensity and duration of exercise. Because of the increasing prevalence of obesity, recent studies have focused on the cellular and molecular mechanisms of obesity-induced insulin resistance in skeletal muscle. Accumulation of intramyocellular lipid may lead to insulin resistance in skeletal muscle. In addition, lipid intermediates (e.g., fatty acyl-coenzyme A, diacylglycerol, and ceramide) impair insulin signaling in skeletal muscle. Recently, emerging evidence linking obesity-induced insulin resistance to excessive lipid oxidation, mitochondrial overload, and mitochondrial oxidative stress have been provided with mitochondrial function. This review will provide a brief comprehensive summary on exercise and skeletal muscle metabolism, and discuss the potential mechanisms of obesity-induced insulin resistance in skeletal muscle.http://www.sciencedirect.com/science/article/pii/S221342201300070Xexerciseinsulin resistanceobesityskeletal muscle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyo-Bum Kwak |
spellingShingle |
Hyo-Bum Kwak Exercise and obesity-induced insulin resistance in skeletal muscle Integrative Medicine Research exercise insulin resistance obesity skeletal muscle |
author_facet |
Hyo-Bum Kwak |
author_sort |
Hyo-Bum Kwak |
title |
Exercise and obesity-induced insulin resistance in skeletal muscle |
title_short |
Exercise and obesity-induced insulin resistance in skeletal muscle |
title_full |
Exercise and obesity-induced insulin resistance in skeletal muscle |
title_fullStr |
Exercise and obesity-induced insulin resistance in skeletal muscle |
title_full_unstemmed |
Exercise and obesity-induced insulin resistance in skeletal muscle |
title_sort |
exercise and obesity-induced insulin resistance in skeletal muscle |
publisher |
Elsevier |
series |
Integrative Medicine Research |
issn |
2213-4220 |
publishDate |
2013-12-01 |
description |
The skeletal muscle in our body is a major site for bioenergetics and metabolism during exercise. Carbohydrates and fats are the primary nutrients that provide the necessary energy required to maintain cellular activities during exercise. The metabolic responses to exercise in glucose and lipid regulation depend on the intensity and duration of exercise. Because of the increasing prevalence of obesity, recent studies have focused on the cellular and molecular mechanisms of obesity-induced insulin resistance in skeletal muscle. Accumulation of intramyocellular lipid may lead to insulin resistance in skeletal muscle. In addition, lipid intermediates (e.g., fatty acyl-coenzyme A, diacylglycerol, and ceramide) impair insulin signaling in skeletal muscle. Recently, emerging evidence linking obesity-induced insulin resistance to excessive lipid oxidation, mitochondrial overload, and mitochondrial oxidative stress have been provided with mitochondrial function. This review will provide a brief comprehensive summary on exercise and skeletal muscle metabolism, and discuss the potential mechanisms of obesity-induced insulin resistance in skeletal muscle. |
topic |
exercise insulin resistance obesity skeletal muscle |
url |
http://www.sciencedirect.com/science/article/pii/S221342201300070X |
work_keys_str_mv |
AT hyobumkwak exerciseandobesityinducedinsulinresistanceinskeletalmuscle |
_version_ |
1725655675805106176 |