Follow-up Evaluation of Association between Weight Changes, Metabolic, and Hormonal Outcomes in Children – a Single-center Pilot Study
Introduction: Fasting blood glucose, insulin level, and lipid profile are the minimal tests according to the Romanian guidelines to evaluate obese children. Cross-sectional studies for pediatric obesity in Romania focused only on epidemiology and management. Aim: Our study aimed to eval...
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doaj-891b7b7c35ac4fd3bc54dfa398577e8f2020-12-31T18:00:36ZengPensoft PublishersFolia Medica 1314-21432020-12-0162473674510.3897/folmed.62.e5112051120Follow-up Evaluation of Association between Weight Changes, Metabolic, and Hormonal Outcomes in Children – a Single-center Pilot StudyIoana Țaranu0Sorana D. Bolboacă1Victoria Creț2Clinical Emergency Paediatric HospitalIuliu Hațieganu University of Medicine and PharmacyClinical Emergency Paediatric HospitalIntroduction: Fasting blood glucose, insulin level, and lipid profile are the minimal tests according to the Romanian guidelines to evaluate obese children. Cross-sectional studies for pediatric obesity in Romania focused only on epidemiology and management. Aim: Our study aimed to evaluate the metabolic and hormonal changes in association with follow-up bodyweight modifications.Materials and methods: Medical charts of overweight or obese children presenting at the First Paediatric Hospital, Cluj-Napoca from January 2017 to March 2019 were retrospectively evaluated. Anthropometric measures [e.g., body mass index (BMI), and waist circumference] and blood tests such as inflammatory markers (e.g., white blood cell and neutrophil absolute/relative counts, C-reactive protein), metabolic parameters (e.g., liver enzymes, uric acid, fasting blood glucose, triglycerides, high-density lipoprotein-cholesterol), fasting blood insulin, and cortisol levels were evaluated.Results: Twenty-two overweight or obese children (17 girls, median age of 13 years) monitored on median for 7.5 months were in-cluded in the study. Blood glucose level significantly decreased (p=0.010) and fasting insulin levels increased (p=0.051) at follow-up evaluation, independently of BMI-for-age z-score. Fasting insulin levels were associated with waist circumference (Spearman’s rank cor-relation coefficient) ρ=0.58, p=0.030). BMI-for-age z-score proved to be associated with the C-reactive protein level at baseline (ρ=0.70, p=0.036, n=9) and high-density lipoprotein cholesterol at follow-up (ρ=-0.52, p=0.033, n=17).Conclusions: Present analysis found changes in fasting insulin levels in relation to the abdominal circumference and high-density lipoprotein cholesterol and C-reactive protein levels in relation to BMI-for-age z-score in obese children. https://foliamedica.bg/article/51120/download/pdf/follow-up studypediatric obesitypractice guide |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ioana Țaranu Sorana D. Bolboacă Victoria Creț |
spellingShingle |
Ioana Țaranu Sorana D. Bolboacă Victoria Creț Follow-up Evaluation of Association between Weight Changes, Metabolic, and Hormonal Outcomes in Children – a Single-center Pilot Study Folia Medica follow-up study pediatric obesity practice guide |
author_facet |
Ioana Țaranu Sorana D. Bolboacă Victoria Creț |
author_sort |
Ioana Țaranu |
title |
Follow-up Evaluation of Association between Weight Changes, Metabolic, and Hormonal Outcomes in Children – a Single-center Pilot Study |
title_short |
Follow-up Evaluation of Association between Weight Changes, Metabolic, and Hormonal Outcomes in Children – a Single-center Pilot Study |
title_full |
Follow-up Evaluation of Association between Weight Changes, Metabolic, and Hormonal Outcomes in Children – a Single-center Pilot Study |
title_fullStr |
Follow-up Evaluation of Association between Weight Changes, Metabolic, and Hormonal Outcomes in Children – a Single-center Pilot Study |
title_full_unstemmed |
Follow-up Evaluation of Association between Weight Changes, Metabolic, and Hormonal Outcomes in Children – a Single-center Pilot Study |
title_sort |
follow-up evaluation of association between weight changes, metabolic, and hormonal outcomes in children – a single-center pilot study |
publisher |
Pensoft Publishers |
series |
Folia Medica |
issn |
1314-2143 |
publishDate |
2020-12-01 |
description |
Introduction: Fasting blood glucose, insulin level, and lipid profile are the minimal tests according to the Romanian guidelines to evaluate obese children. Cross-sectional studies for pediatric obesity in Romania focused only on epidemiology and management. Aim: Our study aimed to evaluate the metabolic and hormonal changes in association with follow-up bodyweight modifications.Materials and methods: Medical charts of overweight or obese children presenting at the First Paediatric Hospital, Cluj-Napoca from January 2017 to March 2019 were retrospectively evaluated. Anthropometric measures [e.g., body mass index (BMI), and waist circumference] and blood tests such as inflammatory markers (e.g., white blood cell and neutrophil absolute/relative counts, C-reactive protein), metabolic parameters (e.g., liver enzymes, uric acid, fasting blood glucose, triglycerides, high-density lipoprotein-cholesterol), fasting blood insulin, and cortisol levels were evaluated.Results: Twenty-two overweight or obese children (17 girls, median age of 13 years) monitored on median for 7.5 months were in-cluded in the study. Blood glucose level significantly decreased (p=0.010) and fasting insulin levels increased (p=0.051) at follow-up evaluation, independently of BMI-for-age z-score. Fasting insulin levels were associated with waist circumference (Spearman’s rank cor-relation coefficient) ρ=0.58, p=0.030). BMI-for-age z-score proved to be associated with the C-reactive protein level at baseline (ρ=0.70, p=0.036, n=9) and high-density lipoprotein cholesterol at follow-up (ρ=-0.52, p=0.033, n=17).Conclusions: Present analysis found changes in fasting insulin levels in relation to the abdominal circumference and high-density lipoprotein cholesterol and C-reactive protein levels in relation to BMI-for-age z-score in obese children.  |
topic |
follow-up study pediatric obesity practice guide |
url |
https://foliamedica.bg/article/51120/download/pdf/ |
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