Parallel Changes in Intracellular Water Volume and pH Induced by NH3/NH4+ Exposure in Single Neuroblastoma Cells

Parallel Changes in Intracellular Water Volume and pH Induced by NH3/NH4+ Exposure in Single Neuroblastoma Cells

Background: Increased blood levels of ammonia (NH3) and ammonium (NH4+), i.e. hyperammonemia, leads to cellular brain edema in humans with acute liver failure. The pathophysiology of this edema is poorly understood. This is partly due to incomplete understanding of the osmotic effects of the pair NH...

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Bibliographic Details
Main Authors: Víctor M. Blanco, Martín S. Márquez, Francisco J. Alvarez-Leefmans
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ammonium
Ammonia
Isosmotic cell swelling
Isosmotic cell shrinkage
Isosmotic regulatory volume decrease
Isosmotic regulatory volume increase
Hyperammonemia
Brain edema
Online Access:http://www.karger.com/Article/FullText/356624

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http://www.karger.com/Article/FullText/356624

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