Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants

Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants

The genetic architecture of late-onset Alzheimer disease (AD) in African Americans (AAs) differs from that in persons of European ancestry. In addition to APOE, genome-wide association studies (GWASs) of AD in AA samples have implicated ABCA7, COBL, and SLC10A2 as AA-AD risk genes. Previously, we id...

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Bibliographic Details
Main Authors: Mark W. Logue, Daniel Lancour, John Farrell, Irina Simkina, M. Daniele Fallin, Kathryn L. Lunetta, Lindsay A. Farrer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer disease
sequencing
AKAP9
ABCA7
rare variant
African Americans
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00592/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00592/full

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