mRNA-Expression of <em>KRT5</em> and <em>KRT20</em> Defines Distinct Prognostic Subgroups of Muscle-Invasive Urothelial Bladder Cancer Correlating with Histological Variants

mRNA-Expression of <em>KRT5</em> and <em>KRT20</em> Defines Distinct Prognostic Subgroups of Muscle-Invasive Urothelial Bladder Cancer Correlating with Histological Variants

Recently, muscle-invasive bladder cancer (MIBC) has been subclassified by gene expression profiling, with a substantial impact on therapy response and patient outcome. We tested whether these complex molecular subtypes of MIBC can be determined by mRNA detection of keratin 5 (<i>KRT5</i>...

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Bibliographic Details
Main Authors: Markus Eckstein, Ralph Markus Wirtz, Matthias Gross-Weege, Johannes Breyer, Wolfgang Otto, Robert Stoehr, Danijel Sikic, Bastian Keck, Sebastian Eidt, Maximilian Burger, Christian Bolenz, Katja Nitschke, Stefan Porubsky, Arndt Hartmann, Philipp Erben
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
Bladder cancer
muscle-invasive bladder cancer
molecular diagnostics
molecular subtyping
<i>KRT5</i>
<i>KRT20</i>
Online Access:https://www.mdpi.com/1422-0067/19/11/3396

Internet

https://www.mdpi.com/1422-0067/19/11/3396

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