COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL
Objective: To compare Solifenacin versus solifenacin plus tamsulosin in terms of international prostate symptom score (IPSS) for lower urinary tract symptoms (LUTS) in patients with unilateral double-J (DJ) ureteric stents. Study Design: Comparative cross sectional study. Place and Duration of...
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The Army Press
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doaj-8a1365e6cec04bcdbff60316cc2472e02021-08-26T10:03:49ZengThe Army PressPakistan Armed Forces Medical Journal0030-96482411-88422021-02-01711455010.51253/pafmj.v71i1.26172617COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIALMuhammad Tanveer Sajid0Sami Ur Rehman1Muhammad Akmal2Hussain Ahmad3Zahoor Iqbal Mirza4Arshad Mahmood5Armed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi PakistanObjective: To compare Solifenacin versus solifenacin plus tamsulosin in terms of international prostate symptom score (IPSS) for lower urinary tract symptoms (LUTS) in patients with unilateral double-J (DJ) ureteric stents. Study Design: Comparative cross sectional study. Place and Duration of Study: Armed Forces Institute of Urology, Rawalpindi from Sep 2018 to Feb 2019. Methodology: A total of two hundred (n=200) patients of either gender aged 20-50 years, who underwent unilateral DJ stenting for different endourological procedures, were enrolled after satisfying inclusion/exclusion criteria and then randomly allocated to group A (Solifenacin 5mg once daily (OD) ± placebo for 2 weeks) or group B (Solifenacin 5mg OD ± Tamsulosin 0.4 mg OD for 2 weeks) respectively. Baseline (1st post-operative day) and Post 02 weeks treatment IPSS was recorded and analyzed. Results: Mean age of presentation in group A and group B was 41.11 ± 6.45 vs 39.86 ± 5.34 years with p-value 0.14. Majority of patients in both groups were male (34% female in group A while 31% in group B, difference being statistically insignificant p 0.65). Baseline IPSS in group A and group B was 10.33 ± 2.72 vs 10.46 ± 3.12 with pvalue 0.76 (statistically insignificant) while post 02 weeks treatment IPSS in group A and B was 9.20 ± 2.67 vs 7.88 ± 2.63 respectively with p-value <0.001, the difference being statistically significant. Conclusions: Current study revealed significant advantage of combination therapy (solifenacin ± tamsulosin) compared with solifenacin monotherapy in lowering LUTS based on IPSS in patients having unilateral......https://pafmj.org/index.php/PAFMJ/article/view/2617lutssolifenacinureteric stent-related symptomstamsulosinipss |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Muhammad Tanveer Sajid Sami Ur Rehman Muhammad Akmal Hussain Ahmad Zahoor Iqbal Mirza Arshad Mahmood |
spellingShingle |
Muhammad Tanveer Sajid Sami Ur Rehman Muhammad Akmal Hussain Ahmad Zahoor Iqbal Mirza Arshad Mahmood COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL Pakistan Armed Forces Medical Journal luts solifenacin ureteric stent-related symptoms tamsulosin ipss |
author_facet |
Muhammad Tanveer Sajid Sami Ur Rehman Muhammad Akmal Hussain Ahmad Zahoor Iqbal Mirza Arshad Mahmood |
author_sort |
Muhammad Tanveer Sajid |
title |
COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL |
title_short |
COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL |
title_full |
COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL |
title_fullStr |
COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL |
title_full_unstemmed |
COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL |
title_sort |
comparison of solifenacin versus combination of solifenacin and tamsulosin in improving unilateral double-j stent related lower urinary tract symptoms - a prospective randomized control trial |
publisher |
The Army Press |
series |
Pakistan Armed Forces Medical Journal |
issn |
0030-9648 2411-8842 |
publishDate |
2021-02-01 |
description |
Objective: To compare Solifenacin versus solifenacin plus tamsulosin in terms of international prostate symptom score (IPSS) for lower urinary tract symptoms (LUTS) in patients with unilateral double-J (DJ) ureteric stents.
Study Design: Comparative cross sectional study.
Place and Duration of Study: Armed Forces Institute of Urology, Rawalpindi from Sep 2018 to Feb 2019.
Methodology: A total of two hundred (n=200) patients of either gender aged 20-50 years, who underwent
unilateral DJ stenting for different endourological procedures, were enrolled after satisfying inclusion/exclusion
criteria and then randomly allocated to group A (Solifenacin 5mg once daily (OD) ± placebo for 2 weeks) or group B (Solifenacin 5mg OD ± Tamsulosin 0.4 mg OD for 2 weeks) respectively. Baseline (1st post-operative day) and Post 02 weeks treatment IPSS was recorded and analyzed.
Results: Mean age of presentation in group A and group B was 41.11 ± 6.45 vs 39.86 ± 5.34 years with p-value 0.14. Majority of patients in both groups were male (34% female in group A while 31% in group B, difference being statistically insignificant p 0.65). Baseline IPSS in group A and group B was 10.33 ± 2.72 vs 10.46 ± 3.12 with pvalue 0.76 (statistically insignificant) while post 02 weeks treatment IPSS in group A and B was 9.20 ± 2.67 vs 7.88 ± 2.63 respectively with p-value <0.001, the difference being statistically significant.
Conclusions: Current study revealed significant advantage of combination therapy (solifenacin ± tamsulosin)
compared with solifenacin monotherapy in lowering LUTS based on IPSS in patients having unilateral...... |
topic |
luts solifenacin ureteric stent-related symptoms tamsulosin ipss |
url |
https://pafmj.org/index.php/PAFMJ/article/view/2617 |
work_keys_str_mv |
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