Identification and Characterization of Adipose Tissue-Derived Human Antibodies With “Anti-self” Specificity

Identification and Characterization of Adipose Tissue-Derived Human Antibodies With “Anti-self” Specificity

We have previously shown that the human obese adipose tissue (AT) contributes to increased secretion of adipocyte-specific IgG antibodies in individuals with obesity. This occurs without any exogenous stimulation, because the ongoing process of cell death in the obese AT leads to the release of “sel...

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Bibliographic Details
Main Authors: Daniela Frasca, Alain Diaz, Maria Romero, Denisse Garcia, Diya Jayram, Seth Thaller, Maria del Carmen Piqueras, Sanjoy Bhattacharya, Bonnie B. Blomberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
adipose tissue
autoimmune antibodies
adipocytes
antigen presentation
B cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00392/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00392/full

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