Association of Class I Human Leukocyte Antigen in Iraqi Patients with Hodgkin’s Lymphoma

• Main Author: Ruqaya M. Al-Barzinji
• Format: Article
• Language: English
• Published: University of Zakho 2013-09-01
• Series: Science Journal of University of Zakho
• Subjects: Class I human leukocyte antigen; Hodgkin’s lymphoma
• Online Access: https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/286

Objective:- To assess the correlation between human leukocytes antigen class I in Iraqi patients with Hodgkin’s lymphoma. Subject and Methods:-  A study was conducted in period between the June 2003 and November, 2004. Study groups included 80 newly diagnosed Hodgkin’s lymphoma patients and two control groups, patient controls which include 50 newly diagnosed by Non Hodgkin’s lymphoma and 50 healthy controls. Antibody-Mediated complement dependent cytotoxicity assay was done by treating sample of patient's lymphocytes with a panel of anti- human leukocyte antigen antisera and complement. Results:- The frequency expression of human leukocyte antigen- A1, A28, B5, B51 and Cw7 was significantly greater in Hodgkin’s lymphoma patients compared to healthy control group  with    (p <0.001) for human leukocyte antigen- A1, A28 and Cw7 and (p <0.01) for B5 and B51.  Conclusion:-   Human leukocyte antigen- A1, A28, B5, B51 and Cw7 are more related with Hodgkin’s lymphoma in Iraqi population that reflects allelic association to Hodgkin’s lymphoma.