TRPC1/5-CaV3 Complex Mediates Leptin-Induced Excitability in Hypothalamic Neurons

TRPC1/5-CaV3 Complex Mediates Leptin-Induced Excitability in Hypothalamic Neurons

Leptin regulates hypothalamic POMC+ (pro-opiomelanocortin) neurons by inducing TRPC (Transient Receptor Potential Cation) channel-mediate membrane depolarization. The role of TRPC channels in POMC neuron excitability is clearly established; however, it remains unknown whether their activity alone is...

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Bibliographic Details
Main Authors: Paula P. Perissinotti, Elizabeth Martínez-Hernández, Erika S. Piedras-Rentería
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neuroscience
Subjects:
CaV3.1
CaV3.2
TRPC channel
hypothalamus
leptin
POMC
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.679078/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.679078/full

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