Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development

Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development

A growing body of evidence suggests that low nephron numbers at birth can increase the risk of chronic kidney disease or hypertension later in life. Environmental stressors, such as maternal malnutrition, medication and smoking, can influence renal size at birth. Using metanephric organ cultures to...

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Bibliographic Details
Main Authors: Lars Fuhrmann, Saskia Lindner, Alexander-Thomas Hauser, Clemens Höse, Oliver Kretz, Clemens D. Cohen, Maja T. Lindenmeyer, Wolfgang Sippl, Manfred Jung, Tobias B. Huber, Nicola Wanner
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
renal development
nephron number
diabetic nephropathy
epigenetic regulation
iron deficiency
DNA methylation
Online Access:https://www.mdpi.com/1422-0067/22/8/4157

Internet

https://www.mdpi.com/1422-0067/22/8/4157

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