Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3

Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3

Abstract Sulforaphane (SFN), an active compound in cruciferous vegetables, has been characterized by its antiproliferative capacity. We investigated the role and molecular mechanism through which SFN regulates proliferation and self-renewal of lung cancer stem cells. CD133+ cells were isolated with...

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Bibliographic Details
Main Authors: Fanping Wang, Yanwei Sun, Xiaoyu Huang, Caijuan Qiao, Wenrui Zhang, Peijun Liu, Mingyong Wang
Format: Article
Language:English
Published: SpringerOpen 2021-08-01
Series:AMB Express
Subjects:
Sulforaphane
Lung cancer
Cancer stem cell
Sonic Hedgehog Signaling Pathway
Human polyhomeotic homolog 3
Online Access:https://doi.org/10.1186/s13568-021-01281-x

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