CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

Human papilloma virus (HPV)-induced cervical cancer constitutively expresses viral E6/E7 oncoproteins and is an excellent target for T cell-based immunotherapy. However, not all tumor-infiltrating T cells confer equal benefit to patients, with epithelial T cells being superior to stromal T cells. To...

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Bibliographic Details
Main Authors: Fenne L. Komdeur, Thalina M. Prins, Stephanie van de Wall, Annechien Plat, G. Bea A. Wisman, Harry Hollema, Toos Daemen, David N. Church, Marco de Bruyn, Hans W. Nijman
Format: Article
Language:English
Published: Taylor & Francis Group 2017-09-01
Series:OncoImmunology
Subjects:
cd103
cervical cancer
intraepithelial t cells
therapeutic vaccination
tumor-infiltrating lymphocytes
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1338230

Internet

http://dx.doi.org/10.1080/2162402X.2017.1338230

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