Vascular Complications in Patients with Chronic Pancreatitis
Introduction: Chronic pancreatitis (CP) is a long-standing progressive inflammation of the pancreas, which can lead to a variety of vascular complications, such as splanchnic venous thrombosis (VT) and arterial pseudoaneurysm (PA). There is a lack of studies on vascular complications in Scandinavian...
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doaj-8c6a152a953145d284452c81456cccf12021-08-26T13:56:00ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-01103720372010.3390/jcm10163720Vascular Complications in Patients with Chronic PancreatitisMiroslav Vujasinovic0Ana Dugic1Amar Nouri2Torkel B Brismar3Francisco Baldaque-Silva4Ebba Asplund5Wiktor Rutkowski6Poya Ghorbani7Ernesto Sparrelid8Hannes Hagström9J.-Matthias Löhr10Department of Upper Abdominal Diseases, Karolinska University Hospital, 141 86 Stockholm, SwedenDepartment of Medicine, Huddinge, Karolinska Institutet,141 86 Stockholm, SwedenDepartment of Medicine, Huddinge, Karolinska Institutet,141 86 Stockholm, SwedenDepartment of Radiology, Karolinska University Hospital, 141 86 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 141 86 Stockholm, SwedenDepartment of Medicine, Huddinge, Karolinska Institutet,141 86 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 141 86 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 141 86 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 141 86 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 141 86 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 141 86 Stockholm, SwedenIntroduction: Chronic pancreatitis (CP) is a long-standing progressive inflammation of the pancreas, which can lead to a variety of vascular complications, such as splanchnic venous thrombosis (VT) and arterial pseudoaneurysm (PA). There is a lack of studies on vascular complications in Scandinavian countries. Methods: We performed a retrospective analysis of medical records of patients with CP identified from the Karolinska University Hospital database between 2003 and 2018. A total of 394 patients with definite CP were included in the study. Results: There were 33 patients with vascular complications, with a median age of 62 (IQR 55–72) years. The cumulative incidence of vascular events was 3.2% at 5 years. Thirty patients had isolated VT, whereas three patients had PA (7.6% and 0.8%, respectively). Isolated splenic vein thrombosis was most common (53.3%), followed by a combination with other splanchnic veins. PA was found in the splenic artery in two patients and in the left gastric artery in one patient. Varices were present in three (10%) patients; variceal bleeding was not recorded. All patients had asymptomatic splanchnic VT, most with chronic VT with developed collaterals (83.3% had abdominal collateral vessels). Nearly two-thirds of patients with VT (63.3%) received no treatment, whereas 11 (36.6%) were treated with anticoagulants. Pseudocysts and alcoholic etiology of CP are risk factors for vascular complications. Conclusions: The cumulative incidence of vascular complications was 3.2% at 5 years. Splanchnic VT is more common than PA. Patients were asymptomatic with no variceal bleeding, explained by well-developed collateral vessels and strong study inclusion criteria.https://www.mdpi.com/2077-0383/10/16/3720chronic pancreatitissplanchnic circulationhepatic vein thrombosispseudoaneurysmvascular complications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miroslav Vujasinovic Ana Dugic Amar Nouri Torkel B Brismar Francisco Baldaque-Silva Ebba Asplund Wiktor Rutkowski Poya Ghorbani Ernesto Sparrelid Hannes Hagström J.-Matthias Löhr |
spellingShingle |
Miroslav Vujasinovic Ana Dugic Amar Nouri Torkel B Brismar Francisco Baldaque-Silva Ebba Asplund Wiktor Rutkowski Poya Ghorbani Ernesto Sparrelid Hannes Hagström J.-Matthias Löhr Vascular Complications in Patients with Chronic Pancreatitis Journal of Clinical Medicine chronic pancreatitis splanchnic circulation hepatic vein thrombosis pseudoaneurysm vascular complications |
author_facet |
Miroslav Vujasinovic Ana Dugic Amar Nouri Torkel B Brismar Francisco Baldaque-Silva Ebba Asplund Wiktor Rutkowski Poya Ghorbani Ernesto Sparrelid Hannes Hagström J.-Matthias Löhr |
author_sort |
Miroslav Vujasinovic |
title |
Vascular Complications in Patients with Chronic Pancreatitis |
title_short |
Vascular Complications in Patients with Chronic Pancreatitis |
title_full |
Vascular Complications in Patients with Chronic Pancreatitis |
title_fullStr |
Vascular Complications in Patients with Chronic Pancreatitis |
title_full_unstemmed |
Vascular Complications in Patients with Chronic Pancreatitis |
title_sort |
vascular complications in patients with chronic pancreatitis |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-08-01 |
description |
Introduction: Chronic pancreatitis (CP) is a long-standing progressive inflammation of the pancreas, which can lead to a variety of vascular complications, such as splanchnic venous thrombosis (VT) and arterial pseudoaneurysm (PA). There is a lack of studies on vascular complications in Scandinavian countries. Methods: We performed a retrospective analysis of medical records of patients with CP identified from the Karolinska University Hospital database between 2003 and 2018. A total of 394 patients with definite CP were included in the study. Results: There were 33 patients with vascular complications, with a median age of 62 (IQR 55–72) years. The cumulative incidence of vascular events was 3.2% at 5 years. Thirty patients had isolated VT, whereas three patients had PA (7.6% and 0.8%, respectively). Isolated splenic vein thrombosis was most common (53.3%), followed by a combination with other splanchnic veins. PA was found in the splenic artery in two patients and in the left gastric artery in one patient. Varices were present in three (10%) patients; variceal bleeding was not recorded. All patients had asymptomatic splanchnic VT, most with chronic VT with developed collaterals (83.3% had abdominal collateral vessels). Nearly two-thirds of patients with VT (63.3%) received no treatment, whereas 11 (36.6%) were treated with anticoagulants. Pseudocysts and alcoholic etiology of CP are risk factors for vascular complications. Conclusions: The cumulative incidence of vascular complications was 3.2% at 5 years. Splanchnic VT is more common than PA. Patients were asymptomatic with no variceal bleeding, explained by well-developed collateral vessels and strong study inclusion criteria. |
topic |
chronic pancreatitis splanchnic circulation hepatic vein thrombosis pseudoaneurysm vascular complications |
url |
https://www.mdpi.com/2077-0383/10/16/3720 |
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