Correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia

Objective: To investigate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia. Methods: A total of 183 healthy second-trimester pregnant women who received antenatal care in this hospital between December 2015 and Decembe...

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Main Authors: Xi-Ping Hong, Jie Xi
Format: Article
Language:English
Published: Editorial Board of Journal of Hainan Medical University 2018-07-01
Series:Journal of Hainan Medical University
Subjects:
Online Access:http://www.hnykdxxb.com/PDF/201814/14.pdf
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spelling doaj-8dc460241df74b22aea847e2c11fab092020-11-25T00:54:37ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372018-07-0124145457Correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsiaXi-Ping Hong0Jie Xi1Obstetrics Department, Shanghai Jiading Maternity & Infant Health Hospital, Shanghai, 201821Obstetrics Department, Shanghai Jiading Maternity & Infant Health Hospital, Shanghai, 201821Objective: To investigate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia. Methods: A total of 183 healthy second-trimester pregnant women who received antenatal care in this hospital between December 2015 and December 2017 were selected as the normal control group, and 62 second-trimester pregnant women with preeclampsia who received antenatal care in this hospital during the same period were selected as the preeclampsia group. The difference of sFlt-1/PLGF ratio in the urine was compared between the two groups of pregnant women, and the expression levels of invasion-related genes and apoptosis-related genes in the placental tissues were detected. The Pearson test was adopted to further evaluate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia. Results: Urine sFlt-1/PLGF ratio of preeclampsia group was significantly higher than that in normal control group; Rho, ROCK, Notch-1, MMP9 and LAMA4 mRNA expression in placental tissues of preeclampsia group were lower than those of normal control group whereas CDKN1C mRNA expression was higher than that of normal control group; Bcl-2 and Survivin mRNA expression in placental tissues of preeclampsia group were lower than those of normal control group whereas Bax, Caspase-3 and Caspase-8 mRNA expression were higher than those of normal control group. Correlation analysis showed that the urine sFlt-1/PLGF ratio of pregnant women with preeclampsia was directly correlated with the expression of placental trophoblast invasion-related genes and apoptosis-related genes in pregnant women with preeclampsia. Conclusion: The sFlt-1/PLGF ratio abnormally increases in the urine of pregnant women with preeclampsia, which can further aggravate the abnormal invasion and apoptosis of placental trophoblast cells.http://www.hnykdxxb.com/PDF/201814/14.pdfPreeclampsiasFlt-1/PLGF ratioInvasionApoptosis
collection DOAJ
language English
format Article
sources DOAJ
author Xi-Ping Hong
Jie Xi
spellingShingle Xi-Ping Hong
Jie Xi
Correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia
Journal of Hainan Medical University
Preeclampsia
sFlt-1/PLGF ratio
Invasion
Apoptosis
author_facet Xi-Ping Hong
Jie Xi
author_sort Xi-Ping Hong
title Correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia
title_short Correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia
title_full Correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia
title_fullStr Correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia
title_full_unstemmed Correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia
title_sort correlation of urine sflt-1/plgf ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia
publisher Editorial Board of Journal of Hainan Medical University
series Journal of Hainan Medical University
issn 1007-1237
1007-1237
publishDate 2018-07-01
description Objective: To investigate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia. Methods: A total of 183 healthy second-trimester pregnant women who received antenatal care in this hospital between December 2015 and December 2017 were selected as the normal control group, and 62 second-trimester pregnant women with preeclampsia who received antenatal care in this hospital during the same period were selected as the preeclampsia group. The difference of sFlt-1/PLGF ratio in the urine was compared between the two groups of pregnant women, and the expression levels of invasion-related genes and apoptosis-related genes in the placental tissues were detected. The Pearson test was adopted to further evaluate the correlation of urine sFlt-1/PLGF ratio with abnormal trophoblast invasion and apoptosis in pregnant women with preeclampsia. Results: Urine sFlt-1/PLGF ratio of preeclampsia group was significantly higher than that in normal control group; Rho, ROCK, Notch-1, MMP9 and LAMA4 mRNA expression in placental tissues of preeclampsia group were lower than those of normal control group whereas CDKN1C mRNA expression was higher than that of normal control group; Bcl-2 and Survivin mRNA expression in placental tissues of preeclampsia group were lower than those of normal control group whereas Bax, Caspase-3 and Caspase-8 mRNA expression were higher than those of normal control group. Correlation analysis showed that the urine sFlt-1/PLGF ratio of pregnant women with preeclampsia was directly correlated with the expression of placental trophoblast invasion-related genes and apoptosis-related genes in pregnant women with preeclampsia. Conclusion: The sFlt-1/PLGF ratio abnormally increases in the urine of pregnant women with preeclampsia, which can further aggravate the abnormal invasion and apoptosis of placental trophoblast cells.
topic Preeclampsia
sFlt-1/PLGF ratio
Invasion
Apoptosis
url http://www.hnykdxxb.com/PDF/201814/14.pdf
work_keys_str_mv AT xipinghong correlationofurinesflt1plgfratiowithabnormaltrophoblastinvasionandapoptosisinpregnantwomenwithpreeclampsia
AT jiexi correlationofurinesflt1plgfratiowithabnormaltrophoblastinvasionandapoptosisinpregnantwomenwithpreeclampsia
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