In Vivo Genome and Methylome Adaptation of cag-Negative Helicobacter pylori during Experimental Human Infection

In Vivo Genome and Methylome Adaptation of cag-Negative Helicobacter pylori during Experimental Human Infection

Exceptional genetic diversity and variability are hallmarks of Helicobacter pylori, but the biological role of this plasticity remains incompletely understood. Here, we had the rare opportunity to investigate the molecular evolution during the first weeks of H. pylori infection by comparing the geno...

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Bibliographic Details
Main Authors: Iratxe Estibariz, Florent Ailloud, Sabrina Woltemate, Boyke Bunk, Cathrin Spröer, Jörg Overmann, Toni Aebischer, Thomas F. Meyer, Christine Josenhans, Sebastian Suerbaum
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
dna methylation
helicobacter pylori
adaptive mutations
genome analysis
smrt sequencing
pacbio
miseq illumina
dna modification
methylome
Online Access:https://doi.org/10.1128/mBio.01803-20

Internet

https://doi.org/10.1128/mBio.01803-20

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