A Gemini Cationic Lipid with Histidine Residues as a Novel Lipid-Based Gene Nanocarrier: A Biophysical and Biochemical Study

A Gemini Cationic Lipid with Histidine Residues as a Novel Lipid-Based Gene Nanocarrier: A Biophysical and Biochemical Study

This work reports the synthesis of a novel gemini cationic lipid that incorporates two histidine-type head groups (C<sub>3</sub>(C<sub>16</sub>His)<sub>2</sub>). Mixed with a helper lipid 1,2-dioleoyl-<i>sn</i>-glycero-3-phosphatidyl ethanol amine (DOP...

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Bibliographic Details
Main Authors:	María Martínez-Negro, Laura Blanco-Fernández, Paolo M. Tentori, Lourdes Pérez, Aurora Pinazo, Conchita Tros de Ilarduya, Emilio Aicart, Elena Junquera
Format:	Article
Language:	English
Published:	MDPI AG 2018-12-01
Series:	Nanomaterials
Subjects:	lipid-based gene nanocarrier gemini cationic lipid with histidine residues gene delivery plasmid DNAs transfection cell viability biophysical characterization
Online Access:	https://www.mdpi.com/2079-4991/8/12/1061

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