Anti-Müllerian hormone – a predictor of ovarian reserve
Background: Since women nowadays experience late decision for the delivery of the first child the question of screening strategies for ovarian reserve determination and fertility potential seems to be crucial. As the most reliable marker of ovarian function FSH determination has been used, but the m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Medical Association
2010-06-01
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| Series: | Zdravniški Vestnik |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/270 |
| Summary: | Background: Since women nowadays experience
late decision for the delivery of the first child
the question of screening strategies for ovarian
reserve determination and fertility potential
seems to be crucial. As the most reliable marker
of ovarian function FSH determination has been
used, but the method is limited with fluctuation
from physiologic to pathologic levels up to some
years before exhaustion of ovarian reserve. In the
past ten years determination of anti-Müllerian
hormone (AMH) concentration in serum has
become most relevant. AMH is produced and
secreted by granulosa cells and regulates the development
of primary follicles with inhibitory action
on FSH secretion. AMH does not only predict
the pool of small antral follicles but can also
be a predictor of oocyte quality. In men AMH
determination has been useful in diagnostic procedures
for intersex conditions with abnormal
testicular differentiation, while in women AMH
tends to be the most reliable marker for small antral
follicle pool in premature ovarian failure and
the marker of increased reserve of small antral
follicles in women with polycystic ovaries.
Conclusion: Recent scientific and clinical data
suggest that AMH determination will be used
as the most reliable marker of ovarian follicular
status. |
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| ISSN: | 1318-0347 1581-0224 |