Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine
Abstract Subanesthetic ketamine evokes rapid antidepressant effects in human patients that persist long past ketamine’s chemical half-life of ~2 h. Ketamine’s sustained antidepressant action may be due to modulation of cortical plasticity. We find that ketamine ameliorates depression-like behavior i...
Main Authors: | Steven F. Grieco, Xin Qiao, Kevin G. Johnston, Lujia Chen, Renetta R. Nelson, Cary Lai, Todd C. Holmes, Xiangmin Xu |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-02-01
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Series: | Translational Psychiatry |
Online Access: | https://doi.org/10.1038/s41398-021-01255-4 |
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