Helicobacter pylori VacA Targets Myeloid Cells in the Gastric Lamina Propria To Promote Peripherally Induced Regulatory T-Cell Differentiation and Persistent Infection

Helicobacter pylori VacA Targets Myeloid Cells in the Gastric Lamina Propria To Promote Peripherally Induced Regulatory T-Cell Differentiation and Persistent Infection

Helicobacter pylori has coexisted with humans for at least 60.000 years and has evolved persistence strategies that allow it to evade host immunity and colonize its host for life. The VacA protein is expressed by all H. pylori strains and is required for high-level persistent infection in experiment...

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Bibliographic Details
Main Authors: Aleksandra Altobelli, Michael Bauer, Karelia Velez, Timothy L. Cover, Anne Müller
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mBio
Subjects:
T-cell immunity
T cells
dendritic cells
host-cell interactions
immunomodulation
mucosal infection
regulatory T cells
macrophages
Online Access:https://doi.org/10.1128/mBio.00261-19

Internet

https://doi.org/10.1128/mBio.00261-19

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